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General Biosafety Guidance
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Introduction to Risk Assessment
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Wild Type Influenza Viruses
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Wild Type SARS-CoV
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Examples of Risk Assessment Templates
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Examples Risk Assessments - Presentations
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Recombinant Influenza Virus and SARS-CoV References
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Occupational Medical Services for Biomedical Research |
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General Biosafety Guidance |
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NIH Guidelines for Research Involving Recombinant DNA Molecules |
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Biosafety in Microbiological and Biomedical Laboratories 5th edition |
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USDA ARS CSREES ERS NASS Manual- Chapter 9.4.4 Biosafety Level 3 Agriculture (BSL-3Ag) |
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World Health Organization Laboratory Biosafety Manual 3rd edition |
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Health Canada Material Safety Data Sheets |
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American Biological Safety Association |
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American Industrial Hygiene Association |
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Top of Page |
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Introduction to Risk Assessment |
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Slides from Dr. E. Barkley's presentation |
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NIH Guidelines template |
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Top of Page |
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Information and Biosafety Guidance for Wild Type Influenza Viruses |
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Sections from the NIH Guidelines |
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Sections from the BMBL |
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CDC Update on Avian Influenza A (H5N1) (Aug. 12, 2004) |
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Avian Influenza: USDA Permitting Requirements under 9 CFR 122 (L. A. Thomas presentation) |
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USDA/CDC Select Agent Program: Data Necessary to Consider Select Agent Exclusion Requests Attentuated Strains of Highly Pathogenic Avian Influenza Viruses |
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WHO laboratory biosafety guidelines for handling specimens suspected of containing highly pathogenic avian influenza A/H5 virus |
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WHO Production of pilot lots of inactivated influenza vaccines from reassortants derived from avian influenza viruses |
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Health Canada Biosafety Advisory Highly Pathogenic Avian Influenza |
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United Kingdom Health and Safety Executive Advice on Assessing the Risks of Working with Highly Pathogenic Avian Influenza Virus |
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Avian Influenza Virus Program at the Virginia-Maryland Regional College of Veterinary Medicine |
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Interim CDC-NIH Recommendation for Raising the Biosafety Level for Laboratory Work Involving Noncontemporary Human Influenza (H2N2) Viruses (May 2005) |
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Revisions to the influenza summary statement for the 5th edition of the BMBL (Dr. J Katz presentation at 6/2005 RAC meeting) |
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Harmonization of the NIH Guidelines with other federal Guidances: Biological containment for work with noncontemporary strains of influenza (Dr. K. Harris presentation at 6/2005 RAC meeting) |
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Biosafety Guidance for Wild Type SARS-CoV |
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WHO biosafety Guidelines for handling of SARS specimens |
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WHO post-outbreak biosafety guidelines for handling of SARS-CoV specimens and cultures |
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WHO Alert, verification, and public health management of SARS in the post-outbreak period |
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United Kingdom Health and Safety Advisory Severe acute respiratory syndrome (SARS) |
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Examples of Risk Assessment Templates for Pathogenic Virus Research |
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Influenza viruses |
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Recombinant influenza virus containment |
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Coronaviruses |
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Examples of Risk Assessments |
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Slides from Dr. Y. Kawaoka's presentation: H5N1 and 1918 influenza viruses |
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Slides from Dr. A. Garcia-Sastre's presentation: 1918 influenza virus |
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Slide from Dr. R. Webster's presentation: Containment for HPAI research |
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Slides from Dr. R. Baric's presentation: SARS-CoV |
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Recombinant Influenza Virus and SARS-CoV References |
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Tumpey, T., et al., (2004) Pathogenicity and immunogenicity of influenza viruses with genes from the 1918 pandemic virus, PNAS 101:3166-3171. |
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Webby, R., and R. Webster, (2003) Are we ready for pandemic influenza? Science 302:1519-1522. |
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Enserink, M., (2004) Tiptoeing around Pandora's box, Science 305: 594-595. |
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Holmes, K., and L. Enjuanes, (2003) The SARS coronavirus: A postgenomic era Science 300: 1377-1378. |
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Yount, B. et al., Reverse genetics with a full-length infectious cDNA of severe acute respiratory syndrome coronavirus PNAS 100:12995-13000. |
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